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Hemoglobin Changes After Long-Term Intermittent Work at High Altitude.

Almaz Akunov1,2, Akylbek Sydykov1,3, Turgun Toktash4

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Long-term intermittent high altitude exposure, like that experienced by commuting workers, linearly increases hemoglobin levels. This effect is also associated with body mass index, independent of exposure duration.

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Area of Science:

  • Physiology
  • Environmental Health
  • Altitude Medicine

Background:

  • Chronic high altitude exposure is known to increase red blood cells and hemoglobin.
  • The impact of long-term intermittent hypoxia on hemoglobin concentration remains less understood.

Purpose of the Study:

  • To investigate the relationship between intermittent high altitude exposure and hemoglobin levels in commuting workers.
  • To assess the influence of factors like age, BMI, and occupation on these levels.

Main Methods:

  • Studied 266 healthy males commuting between 3,800m and below 1,700m.
  • Collected data on hemoglobin levels, duration of exposure (0-21 years), and other health metrics.
  • Employed univariate and multivariable regression analyses to identify significant associations.

Main Results:

  • Mean hemoglobin level was 16.2 g/dL.
  • Each year of intermittent high altitude exposure was associated with a statistically significant increase in hemoglobin.
  • Body mass index showed a weak, independent linear relationship with hemoglobin levels.

Conclusions:

  • Hemoglobin concentration demonstrates a linear correlation with the duration of intermittent high altitude exposure.
  • Body mass index is also independently associated with hemoglobin levels in this population.