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The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety
Nathan R Ching1, Amna K Alzghari2, Saeed K Alzghari3
1Chemistry, Texas Christian University, Fort Worth, USA.
Abstract:
Anxiety affects over 260 million people worldwide. Benzodiazepines are a class of agents used in combination with other therapies for the management of anxiety. Lorazepam is a commonly prescribed benzodiazepine metabolized by uridine 5'-diphosphate-glucuronosyltransferases. Herein, we discuss recent findings regarding the pharmacogenetics of uridine 5'-diphosphate-glucuronosyltransferase 2B15 (UGT2B15), lorazepam, and its role in the treatment of anxiety.
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