MODERN ANTICEPTIC HYDROGEL IN TREATMENT OF INFECTIOUS COMPLICATIONS OF WOUNDS IN SURGERY

Area of Science:

• Surgical innovation
• Antimicrobial research
• Wound healing studies

Background:

• Infectious complications are a significant challenge in surgery, particularly with the use of fixation devices.
• Purulent complications frequently occur post-operative interventions.
• Development of effective surgical antiseptics is crucial for patient outcomes.

Purpose of the Study:

• To evaluate the adhesive surgical antiseptic (ASA) «ARGAKOL» for its efficacy in preventing surgical site infections.
• To assess the antimicrobial spectrum of ASA «ARGAKOL».
• To investigate the impact of ASA «ARGAKOL» on wound healing processes.

Main Methods:

• Antimicrobial activity was determined using the twofold serial dilutions in a liquid medium and Cup-suspension methods.
• In vivo experiments were conducted on white outbred rats to assess wound healing.
• Two experimental series were performed: one on «just contaminated» wounds and another on infected wounds with delayed ASA «ARGAKOL» application.

Main Results:

• Preliminary findings indicate that ASA «ARGAKOL» exhibits a broad spectrum of antimicrobial action.
• The study explored the influence of ASA «ARGAKOL» on wound healing in experimental models.
• Experimental data was gathered from two distinct wound models in rats.

Conclusions:

• ASA «ARGAKOL» demonstrates promising broad-spectrum antimicrobial properties.
• Further research is warranted to fully elucidate the role of ASA «ARGAKOL» in surgical infection prevention and wound healing.
• The study provides a foundation for the clinical application of this novel surgical antiseptic.