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Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
Published on: August 23, 2022
[Prevention of gastrointestinal bleeding in patients with advanced burns]
D O Vagner1, K M Krylov2, V G Verbitsky2
1Dzhanelidze St. Petersburg Research Institute for Emergency Care, St. Petersburg, Russia; Mechnikov Northwestern State Medical University of Healthcare Ministry of the Russian Federation, St. Petersburg, Russia.
Aim:
To reduce the incidence of gastrointestinal bleeding in patients with advanced burns by developing a prophylactic algorithm.
Material And Methods:
The study consisted of retrospective group of 488 patients with thermal burns grade II-III over 20% of body surface area and prospective group of 135 patients with a similar thermal trauma. Standard clinical and laboratory examination was applied. Instrumental survey included fibrogastroduodenoscopy, endoscopic pH-metry and invasive volumetric monitoring (PICCO plus). Statistical processing was carried out with Microsoft Office Excel 2007 and IBM SPSS 20.0.
Results:
New algorithm significantly decreased incidence of gastrointestinal bleeding (p<0.001) and mortality rate (p=0.006) in patients with advanced burns.
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