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Spray congealing: a versatile technology for advanced drug-delivery systems
Serena Bertoni1, Luisa S Dolci1, Beatrice Albertini1
1Department of Pharmacy & Biotechnology, University of Bologna, Via S Donato 19/2, 40127 Bologna, Italy.
Therapeutic Delivery
|November 17, 2018
Summary
Spray congealing offers a solvent-free method for creating microparticles. This review explores its pharmaceutical applications and drug delivery systems, highlighting formulation considerations and industrial potential.
Area of Science:
- Pharmaceutical Technology
- Materials Science
- Chemical Engineering
Background:
- Spray congealing is an economical and adaptable technique for microparticle production.
- It avoids the use of organic or aqueous solvents, making it environmentally friendly.
- This method is suitable for various pharmaceutical applications.
Purpose of the Study:
- To provide a comprehensive overview of spray congealing technology in pharmaceuticals.
- To examine spray-congealed drug delivery systems and their formulation aspects.
- To discuss the industrial status, benefits, limitations, and future of this technology.
Main Methods:
- Review of existing literature on spray congealing technology.
- Analysis of principles, equipment, and formulation variables.
- Critical discussion of representative drug delivery system examples.
Main Results:
- Detailed explanation of spray congealing principles and equipment.
- Examination of various spray-congealed drug delivery systems.
- Discussion on formulation design and industrial applications.
Conclusions:
- Spray congealing is a versatile, solvent-free technology with significant pharmaceutical potential.
- Formulation variables play a crucial role in optimizing drug delivery systems.
- The technology presents benefits and limitations, with promising future perspectives in drug delivery.
Keywords:
microencapsulationmultiparticulate drug-delivery systemssolid dispersionsolid lipid microparticlessolvent-free technologyspray chillingspray coolingMore Related Videos
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