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Review and Preview01:10

Review and Preview

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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
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Review and Preview01:13

Review and Preview

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Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
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Random and Systematic Errors01:20

Random and Systematic Errors

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Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
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Systematic Sampling Method01:17

Systematic Sampling Method

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Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
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Propagation of Uncertainty from Systematic Error01:10

Propagation of Uncertainty from Systematic Error

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The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this...
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Systematic Error: Methodological and Sampling Errors01:15

Systematic Error: Methodological and Sampling Errors

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In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
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Related Experiment Video

Updated: Feb 2, 2026

Author Spotlight: Demonstrating Systematic Endobronchial Ultrasound to New Endoscopists
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Modafinil for poststroke patients: A systematic review.

Rafael Leite Pacheco1,2, Carolina de Oliveira Cruz Latorraca1,2, Luciana Di Giovanni Marques da Silva3

  • 1Evidence Based Health Program at Universidade Federal de São Paulo, Sao Paulo, Brazil.

International Journal of Clinical Practice
|November 17, 2018
PubMed
Summary

Modafinil shows uncertain benefits for stroke patients, with limited evidence suggesting potential improvements in fatigue but not disability or cognition. Its routine use is not supported by current research due to low-quality evidence.

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Area of Science:

  • Neurology
  • Pharmacology
  • Systematic Reviews

Background:

  • Stroke is a leading global cause of death and disability.
  • Modafinil, a wakefulness-promoting agent, is being investigated for potential benefits in stroke recovery.

Purpose of the Study:

  • To systematically review the efficacy and safety of modafinil in poststroke patients.
  • To assess modafinil's impact on fatigue, disability, cognition, and quality of life after stroke.

Main Methods:

  • A systematic review was conducted following Cochrane Handbook and PRISMA guidelines.
  • Included two published studies and one ongoing trial, with a total of 77 participants.
  • Analyzed modafinil's effects in adults from 14 days to 3 months poststroke.

Main Results:

  • Limited evidence suggests modafinil may benefit fatigue but not disability or cognition.
  • Clinical and methodological variability precluded meta-analyses.
  • Data on adverse events were scarce, and mortality was not assessed.

Conclusions:

  • Current evidence quality is very low, making the effects of modafinil in stroke patients unclear.
  • The findings do not support the routine clinical use of modafinil for stroke patients.
  • Further high-quality research is needed to determine modafinil's true benefits and harms.