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Published on: September 16, 2012
Clinical Safety and Utility of Pediatric Balloon-assisted Enteroscopy: A Multicenter Prospective Study in Japan
Shin-Ichiro Hagiwara1, Takahiro Kudo2, Fumihiko Kakuta3
1Division of General Pediatrics, Saitama Children's Medical Center, Saitama, Saitama Prefecture.
Insights
Balloon-assisted enteroscopy (BAE) is feasible in pediatric patients across multiple Japanese hospitals. This multicenter study confirms the efficacy of BAE for diagnosing gastrointestinal issues in children.
Area of Science:
- Pediatric Gastroenterology
- Endoscopy
- Medical Devices
Background:
- Balloon-assisted enteroscopy (BAE) benefits in pediatric patients are increasingly recognized.
- Previous BAE data in children primarily comes from single-institution experiences.
- Multi-institutional validation is crucial for establishing pediatric BAE feasibility.
Purpose of the Study:
- To evaluate the feasibility and efficacy of pediatric balloon-assisted enteroscopy (BAE).
- To assess BAE performance across multiple tertiary referral centers in Japan.
- To document diagnostic yield and safety of BAE in pediatric patients.
Main Methods:
- Prospective, multi-institutional observational study.
- Inclusion of pediatric patients (<18 years) undergoing BAE (double-balloon or single-balloon).
- Data collection via standardized questionnaire from April 2014 to March 2017.
Main Results:
- 79 pediatric patients (96 procedures) were enrolled.
- BAE was performed via antegrade and retrograde routes, with the youngest patient aged 1.6 years.
- Overall diagnostic yield for rectal bleeding and abdominal pain was 48%; severe adverse events occurred in 2 patients (hemorrhage, pancreatitis).
Conclusions:
- This study confirms the efficacy of balloon-assisted enteroscopy in pediatric patients.
- BAE is a feasible and valuable diagnostic tool in pediatric gastroenterology.
- Multi-center data supports the broader application of BAE in pediatric care.
Objectives:
The benefit of balloon-assisted enteroscopy (BAE) had been recently documented in pediatric patients, but previous reports are based on single institution experiences. We evaluated the feasibility of pediatric BAE in 8 tertiary referral hospitals throughout Japan.
Methods:
This was a prospective, multi-institutional study. Patients younger than 18 years were enrolled between April 2014 and March 2017 to undergo double-balloon or single-balloon enteroscopy. Data were collected prospectively using a standardized questionnaire.
Results:
We enrolled 79 pediatric patients (96 procedures, 70 boys, 26 girls; median age 12.7 years, range 1-17 years). Antegrade (oral-route) BAE was performed in 20 procedures (lowest body weight 12.9 kg, youngest age 3.7 years), and retrograde (anal-route) BAE in 76 (lowest body weight 10.8 kg, youngest age 1.6 years). Severe adverse events were associated with BAE in 2 patients: 1 with hemorrhage due to polypectomy and 1 with pancreatitis after double-balloon endoscopic retrograde cholangioscopy. No intestinal perforation was reported. Procedure duration of oral-route BAE for diagnosis was significantly longer than anal-route for diagnosis (P < 0.001). The overall diagnostic yield for rectal bleeding/positive fecal occult blood test and abdominal pain was 48%. Among 40 patients referred for diagnosis who did not undergo capsule endoscopy, diagnoses were confirmed in 17 (42.5%) patients after BAE.
Conclusions:
This prospective multicenter observational study documents the efficacy of BAE in pediatric patients.
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