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Updated: Feb 2, 2026

An Anoxia-starvation Model for Ischemia/Reperfusion in C. elegans
Published on: March 11, 2014
Oxygen Starvation Unmasks a Killer
Riley L Svec1, Paul J Hergenrother1
1Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Abstract:
In this issue of Cell Chemical Biology, Jacobsen et al. (2018) investigate the hypoxia selectivity of two cyclolipodepsipeptide natural products bearing a 4-amido-2,4-pentadienoate warhead. A switch in the cell death pathway under hypoxic conditions is observed, suggesting these electrophilic natural products have potential as a prodrug-free approach for treating hypoxic tumors.
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