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Updated: Feb 2, 2026

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
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Cangrelor Induces More Potent Platelet Inhibition without Increasing Bleeding in Resuscitated Patients.

Florian Prüller1, Lukasz Bis2, Oliver Leopold Milke3

  • 1Clinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Graz 8036, Austria. florian.prueller@klinikum-graz.at.

Journal of Clinical Medicine
|November 18, 2018
PubMed
Summary

Intravenous cangrelor provided stronger P2Y12-inhibition than oral agents in myocardial infarction (MI) patients undergoing therapeutic hypothermia (TH). This effective antiplatelet therapy did not increase bleeding risk, showing feasibility in this critical patient group.

Keywords:
acute coronary syndromecangrelorlight transmission tomographymyocardial infarctionplatelet functionresuscitation

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Area of Science:

  • Cardiology
  • Pharmacology
  • Critical Care Medicine

Background:

  • Dual antiplatelet therapy is standard for myocardial infarction (MI) patients after resuscitation and therapeutic hypothermia (TH).
  • Comparing intravenous cangrelor with oral P2Y12-inhibitors is crucial for optimizing antiplatelet effects and bleeding risk in this population.

Purpose of the Study:

  • To prospectively compare the antiplatelet efficacy and bleeding risk of intravenous cangrelor versus oral P2Y12-inhibitors.
  • To evaluate cangrelor's feasibility and effectiveness in patients with MI receiving TH.

Main Methods:

  • Prospective comparison of two matched patient cohorts: CANGRELOR (NCT03445546) and ORAL P2Y12 (NCT02914795).
  • Platelet function testing using light-transmittance aggregometry monitored over 4 days.
  • Assessment of bleeding events using TIMI and BARC criteria, along with blood transfusion rates and hematological parameters.

Main Results:

  • Stronger P2Y12-inhibition was observed with cangrelor compared to oral P2Y12-inhibitors at day 1 (ADP AUC: 26.0 vs. 160.9).
  • This difference diminished as patients transitioned from cangrelor to oral agents.
  • No significant differences in bleeding events (TIMI, BARC), blood transfusions, or changes in Hb/Hct were noted between groups.

Conclusions:

  • Intravenous cangrelor is feasible and effective in resuscitated MI patients treated with TH.
  • Cangrelor demonstrates superior platelet inhibition compared to oral P2Y12-inhibitors without elevating bleeding risk.
  • This suggests cangrelor as a viable option for potent antiplatelet therapy in this high-risk cohort.