Low-level light therapy reduces platelet destruction during extracorporeal circulation

Area of Science:

• Biomedical Engineering
• Photomedicine
• Hematology

Background:

• Extracorporeal circulation, including cardiopulmonary bypass (CPB), causes significant damage to blood cells.
• Low-level light therapy (LLLT) is recognized for its cell-protective effects, particularly in the red/near-infrared spectrum.
• The application of LLLT during CPB has not been previously investigated.

Purpose of the Study:

• To evaluate the protective effects of LLLT on platelets during CPB.
• To determine if LLLT can preserve platelet count and function in a CPB model.

Main Methods:

• A 1-hour CPB model was established in 24 pigs.
• Twelve pigs received LLLT treatment targeting blood within the oxygenator.
• Platelet count, CD62P expression, and aggregation patterns were monitored for 24 hours post-CPB.

Main Results:

• The LLLT group exhibited a less pronounced decrease in platelet count compared to the control group.
• CD62P expression, a marker of platelet activation, remained more stable in the LLLT group.
• Platelets in the LLLT group showed reduced aggregation tendencies post-CPB compared to controls.

Conclusions:

• LLLT demonstrates a protective effect on platelets during CPB.
• LLLT may stabilize platelet function and reduce damage caused by interaction with artificial surfaces during extracorporeal circulation.
• Further research into LLLT as an adjunct therapy for CPB is warranted.