Related Experiment Video
Updated: Feb 2, 2026
08:54
Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
Published on: April 27, 2015
17.4K
Enhanced recovery after liver surgery.
R Brustia1, K Slim2, O Scatton3
1Service de chirurgie digestive, hépatobiliopancreatique et transplantation hépatique, hôpital Pitié Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013 Paris, France; Sorbonne Universités, 21, rue de l'École-de-Médecine, 75006 Paris, France; Unité de Recherche BQR SSPC « Simplification des Soins des Patients Complexes » Université de Picardie Jules Verne, 80080 Amiens, France.
Journal of Visceral Surgery
|November 19, 2018
Summary
Enhanced recovery after surgery programs (ERP) significantly reduce complications by 30-60% in liver surgery, shortening hospital stays. While not impacting readmission or mortality, ERP improves patient outcomes and functional recovery.
Area of Science:
- Hepatobiliary Surgery
- Surgical Outcomes Research
- Multidisciplinary Care Models
Background:
- Enhanced Recovery After Surgery (ERP) programs are proven to reduce complications and hospital stays in digestive surgery.
- Liver surgery has high morbidity and mortality rates, making ERP implementation highly relevant.
- ERP involves preoperative, perioperative, and postoperative measures managed by a multidisciplinary team.
Purpose of the Study:
- To systematically review the efficacy of Enhanced Recovery After Surgery (ERP) programs in liver surgery.
- To evaluate the impact of ERP on complication rates, hospital stay, and functional recovery in liver surgery patients.
Main Methods:
- A systematic narrative review of existing literature.
- Inclusion of studies on ERP in liver surgery performed via laparotomy or laparoscopy.
- Analysis of 30 studies, including randomized trials, cohort studies, and meta-analyses.
Main Results:
- ERP is associated with a 30-60% decrease in overall complications for liver surgery.
- Average length of stay (ALOS) reduced by 2.3 days; functional recovery improved by 2.5 days.
- Laparoscopic surgery independently improves outcomes and should be integrated into ERP.
Conclusions:
- Enhanced Recovery After Surgery (ERP) is a valuable care improvement process for organizing liver surgery.
- Large-scale application of ERP in liver surgery is recommended to enhance patient outcomes.
- Addressing implementation barriers through team leadership and training is crucial for successful ERP adoption.
Related Concept Videos
03:00Self-Evaluation: Self-Enhancement and Self-Verification
5.8K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.8K
01:24Muscle Recovery and Fatigue
4.2K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.2K
01:16Bioavailability Enhancement: Drug Solubility Enhancement
260
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
260
01:27Bioavailability Enhancement: Drug Permeability Enhancement
205
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
205
01:27Liver Histology
4.4K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
4.4K
01:30Liver Physiology
3.8K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.8K