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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
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Regulatory T Cell Plasticity and Stability and Autoimmune Diseases
Runze Qiu1, Liyu Zhou1, Yuanjing Ma1
1School of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Xianlin Dadao 138, Nanjing, 210023, People's Republic of China.
Clinical Reviews in Allergy & Immunology
|November 19, 2018
Summary
Regulatory T cells (Tregs) can become plastic, altering their stability and immune function. This plasticity impacts immune homeostasis and autoimmune disease progression, highlighting the need for further research.
Area of Science:
- Immunology
- Cell Biology
Background:
- CD4+CD25+ regulatory T cells (Tregs) are crucial for immune homeostasis due to their immunosuppressive functions.
- Treg stability, marked by Foxp3 expression, can become abnormal in disease, leading to plastic differentiation.
Purpose of the Study:
- To review the characteristics, functions, and formation of plastic Tregs.
- To summarize Treg stability changes and their impact on immune inhibition and autoimmune disease prognosis.
Main Methods:
- Literature review focusing on Treg plasticity and stability.
- Analysis of phenotypic characteristics, functions, and formation conditions of plastic Tregs.
- Investigation of Treg plasticity and stability in autoimmune diseases.
Main Results:
- Plastic Tregs exhibit features of both Tregs and helper T (Th) cells, secreting cytokines while retaining immunosuppressive capacity.
- Abnormal Treg stability is linked to disease complexity and progression, particularly in autoimmune conditions.
- Treg plasticity and stability significantly influence the prognosis of various autoimmune diseases.
Conclusions:
- Understanding Treg plasticity and stability is vital for comprehending immune dysregulation in autoimmune diseases.
- Further research into Treg dynamics can offer insights into potential therapeutic strategies for immune-related disorders.
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