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Peripartum Cardiomyopathy: Progress in Understanding the Etiology, Management, and Prognosis

Kathryn J Lindley1, Amanda K Verma1, Lori A Blauwet2

  • 1Cardiovascular Division, Washington University in St. Louis, 660 South Euclid Avenue, Box 8086, St Louis, MO 63110, USA.

Heart Failure Clinics
|November 20, 2018
PubMed

Occurring in approximately 1 in 1000 live births in the United States, peripartum cardiomyopathy (PPCM) is characterized by left ventricular ejection fraction reduced to less than 45% near the end of pregnancy or within the first 5 months after delivery. Although the cause of PPCM remains unclear, increasing evidence supports a complex interaction of genetic and environmental factors contributing to angiogenic imbalance, which may lead to myocardial dysfunction in a susceptible woman. This article reviews the progress that has been made regarding understanding of the cause, management, and natural history of PPCM.

Keywords:
DiagnosisHeart failurePeripartum cardiomyopathyPregnancyPrognosis

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