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Advanced Therapies for Advanced Heart Failure in Women
Marlena V Habal1, Kelly Axsom1, Maryjane Farr1
1Department of Medicine, Division of Cardiology, Center for Advanced Cardiac Care, Columbia University Medical Center, 622 West 168th Street PH1273, New York, NY 10032, USA.
Abstract:
Women with advanced heart failure (HF) are underrepresented in trials of short-term and durable mechanical circulatory support although they derive similar benefit. In acute HF, intensive medical and interventional therapies are effective but underutilized. The smaller, newer generation, left ventricular assist devices (LVADs) have increased the feasibility of durable support in women. Women frequently present late, with more comorbidities, emphasizing the need for timely referral. Compared with men, the stroke risk is higher in women with an LVAD. Increased representation in clinical trials and a better understanding of the psychosocial issues affecting women is essential.
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