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Severe Chronic Inflammatory Demyelinating Polyneuropathy Ameliorated following High-dose (3 g/kg) Intravenous

Yusuke Seino1, Takumi Nakamura1, Mie Hirohata1

  • 1Department of Neurology, Hirosaki University Graduate School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|November 20, 2018
PubMed

We report the case of a 53-year-old woman with severe chronic inflammatory demyelinating polyneuropathy (CIDP) who developed progressive tetraplegia with respiratory failure despite receiving a standard dose of intravenous immunoglobulin therapy (IVIg), steroid pulse therapy, plasma exchange, and cyclosporine. We administered high-dose IVIg (3 g/kg; 0.6 g/kg/day for 5 consecutive days at monthly intervals). The patient's muscle weakness gradually improved after IVIg. She recovered completely 2 years after the onset of symptoms. The effects of IVIg treatment in individuals with CIDP may vary in each patient. In patients with refractory CIDP receiving standard-dose IVIg, repeated high-dose IVIg treatment can be considered.

Keywords:
chronic inflammatory demyelinating polyneuropathy (CIDP)high-dose intravenous immunoglobulin therapy (IVIg)pentaplegiarespiratory failure

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