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A basic library of microcomputer programs to obtain immunologically relevant information from protein sequences.

A Sette1, G Doria, L Adorini

  • 1ENEA-Euratom Immunogenetics Group, ENEA C.R.E. Casaccia, Rome, Italy.

International Journal of Bio-Medical Computing
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

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This study introduces simple BASIC programs for analyzing protein sequences, offering insights into structural dissimilarity, secondary structure, and 3D similarity for immunological relevance.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Immunology

Background:

  • Protein sequence analysis is crucial for understanding protein function and immunological relevance.
  • Access to user-friendly computational tools can facilitate this analysis.

Purpose of the Study:

  • To describe a suite of interactive BASIC microcomputer programs for extracting immunologically relevant information from protein sequences.
  • To provide accessible tools for researchers, particularly those using Apple IIE systems.

Main Methods:

  • Development of specific programs: STRUDIS for structural dissimilarity, CHOUFAS for predicted secondary structure, HYDCOR for 3D similarity via hydrophobicity correlation, and HELOC for alpha-helical segment location.
  • Implementation of a general program for running mean calculations (RUNMEAN).

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  • All programs are provided in a BASIC version compatible with the Apple IIE microcomputer.

    • Main Results:

    • The described programs enable the computation of key protein sequence features relevant to immunology.
    • Interactive analysis of protein structural dissimilarity, secondary structure, and 3D similarity is facilitated.
    • Location of alpha-helical segments and running mean calculations are also supported.

    Conclusions:

    • These BASIC programs offer a simple and interactive method for obtaining immunologically relevant data from protein sequences.
    • The tools are designed for accessibility, particularly for users with Apple IIE systems.
    • The programs contribute to the computational toolkit for protein sequence analysis in immunological research.