Related Experiment Video
Updated: Feb 2, 2026
08:01
Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
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The eighth TNM classification for malignant pleural mesothelioma
Lawek Berzenji1, Paul E Van Schil1, Laurens Carp2
1Department of Thoracic and Vascular Surgery, Antwerp University Hospital, Edegem, Belgium.
Translational Lung Cancer Research
|November 20, 2018
Summary
The International Association for the Study of Lung Cancer updated the tumor, node, and metastasis (TNM) staging for malignant pleural mesothelioma. Key changes include revised T and N components and a new definition for stage IV disease.
Area of Science:
- Oncology
- Thoracic Surgery
- Pathology
Background:
- Malignant pleural mesothelioma (MPM) staging is crucial for treatment planning and prognosis.
- The International Association for the Study of Lung Cancer (IASLC) previously established TNM classifications for MPM.
Purpose of the Study:
- To present revisions for the eighth edition of the TNM classification for MPM.
- To establish recommendations for staging MPM based on a large patient database.
Main Methods:
- Analysis of a large international IASLC patient database.
- Survival analysis to evaluate T and N component definitions.
- Review and revision of TNM descriptors for MPM.
Main Results:
- T1a and T1b categories were combined into a single T1 category.
- Tumor thickness was identified as a significant prognostic factor.
- N component descriptors were redefined, combining N1 and N2 into a single N1 category, with previous N3 now classified as N2.
- M1 involvement is recommended as the sole criterion for stage IV disease.
Conclusions:
- The IASLC project has resulted in significant revisions for the eighth TNM classification of MPM.
- International collaborative efforts are vital for developing effective staging systems.
- Future TNM classifications may incorporate tumor thickness as a prognostic tool.
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