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Purification of Mitochondria from Yeast Cells
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Healthy mitochondria for stroke cells.

Eleonora Russo1, Eleonora Napoli2, Cesar V Borlongan1

  • 1Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA.

Brain Circulation
|November 20, 2018
PubMed
Summary
This summary is machine-generated.

Mitochondrial transfer shows promise for stroke treatment. Transplanting healthy mitochondria from stem cells may offer a novel therapeutic strategy for neuroprotection and recovery after stroke.

Keywords:
Astrocytesendothelial cellsmitochondrianeuronsstem cellsstroke

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cell Biology

Background:

  • Stroke is a leading cause of disability with limited treatment options.
  • Healthy mitochondria are crucial for neuroprotection, with astrocytes transferring mitochondria to neurons during stroke.
  • Current astrocyte-to-neuron mitochondrial transfer may be insufficient for robust stroke recovery.

Purpose of the Study:

  • To review the therapeutic potential of mitochondrial transfer for stroke treatment.
  • To explore exogenous stem cells as a source of healthy mitochondria for ischemic cells.
  • To highlight advances in mitochondrial transfer as a novel stroke therapy.

Main Methods:

  • This paper is a review article.
  • Literature search conducted using databases like PubMed.
  • Analysis of recent studies on mitochondrial transfer in stroke models.

Main Results:

  • Mitochondrial transfer from astrocytes to neurons occurs during stroke.
  • Exogenous stem cells can provide healthy mitochondria to ischemic neurons and endothelial cells.
  • Mitochondrial transfer demonstrates therapeutic potential for stroke.

Conclusions:

  • Mitochondrial transfer, particularly from exogenous stem cells, represents a promising novel therapeutic strategy for stroke.
  • This approach targets neuroprotection and potentially aids recovery in both neuronal and endothelial cells affected by stroke.
  • Further research into stem cell-derived mitochondrial transplantation is warranted for stroke treatment.