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Secondary Oxalate Nephropathy: A Systematic Review
Nuttha Lumlertgul1, Monchai Siribamrungwong2, Bertrand L Jaber3,4
1Division of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
Kidney International Reports
|November 20, 2018
Summary
Secondary oxalate nephropathy is a serious kidney disease. Most patients require dialysis, and many do not recover kidney function, highlighting the need for better treatments.
Area of Science:
- Nephrology
- Renal Pathology
- Clinical Medicine
Background:
- Secondary oxalate nephropathy (SON) clinical outcomes are poorly understood.
- A systematic review was conducted to analyze SON characteristics and outcomes.
Purpose of the Study:
- To systematically review and synthesize data on the clinical characteristics and outcomes of patients with secondary oxalate nephropathy.
Main Methods:
- Systematic review of case reports and case series from 1950 to January 2018.
- Inclusion of biopsy-proven oxalate nephropathy in native or transplanted kidneys.
- Meta-analysis of case series data.
Main Results:
- 108 patients were included, with fat malabsorption being the most common cause (88%).
- 55% of patients required dialysis, with 58% remaining dialysis-dependent long-term.
- 33% of patients died, and none achieved complete recovery.
Conclusions:
- Secondary oxalate nephropathy is a rare but severe condition with poor prognosis.
- Over half of affected patients require renal replacement therapy, often permanently.
- Further research is crucial for developing preventive and therapeutic strategies for high-risk individuals.
Keywords:
acute kidney injurychronic kidney diseasenephrolithiasisoxalate nephropathyoxalosissecondary oxalosisMore Related Videos
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