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Malignant tumor cell lines produce interleukin-1-like factor
S Miyauchi1, T Moroyama, S Kyoizumi
1Department of Oral and Maxillofacial Surgery I, Hiroshima University, School of Dentistry, Japan.
Abstract:
Sixty-four malignant cell lines were examined for interleukin-1 (IL-1) activities in their conditioned medium using thymocyte and fibroblast proliferation assays. Sixteen cell lines showed high IL-1 activity. Comparison of these activities with human IL-1 showed similarity between some biological properties. However there was no correlation between cell origin and IL-1 activity. These results suggest the possibility that most malignant cells may produce an IL-1-like factor.