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Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
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Epstein - Barr virus association with plasma cell neoplasms.
Ali Nael1, William W Wu2, Imran Siddiqi3
1Department of Pathology, Children's Hospital of Orange County (CHOC), Orange, California, USA.
Histology and Histopathology
|November 20, 2018
Summary
Epstein-Barr virus (EBV) is rarely associated with plasma cell neoplasms in immunocompetent individuals. When found, EBV in these conditions often presents with plasmablastic features.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Epstein-Barr virus (EBV) is linked to various cancers.
- EBV presence in plasma cell neoplasms is primarily documented in immunocompromised patients.
Purpose of the Study:
- To investigate the association between Epstein-Barr virus (EBV) and plasma cell neoplasms.
- Focus on evaluating EBV in immunocompetent patients with these conditions.
Main Methods:
- Retrospective analysis of 147 plasma cell neoplasm cases.
- Included plasma cell myeloma, plasmacytoma, and monoclonal gammopathy diagnoses.
- Assessed EBV status in both immunocompromised and immunocompetent individuals.
Main Results:
- EBV was detected in 6 out of 147 patients.
- Three cases were in immunocompromised patients (HIV, post-transplant).
- Three cases were in immunocompetent patients with plasmacytoma and plasmablastic features.
Conclusions:
- Epstein-Barr virus (EBV) shows a low association with plasma cell neoplasms in immunocompetent patients.
- EBV was absent in all immunocompetent plasma cell myeloma cases.
- EBV expression in plasma cell neoplasms is typically associated with plasmablastic features.
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