Alkaloids from the Tuber of Stephania cf. rotunda

Chemical investigation of the tuber of Stephania cf. rotunda collected in Vietnam led to the isolation of a new stephaoxocane-type alkaloid, stepharotudine (1), twenty -eight known alkaloids, and two known amides. The chemical structures of the isolated compounds were determined by spectroscopic and chemical methods. The absolute configuration of the new compound was determined from its CD spectrum and by 1H NMR analyses of its MPA esters. For the known alkaloids ()crebanme-β-N-oxide (2), uthongine (3), and palmatrubine (4), fully assigned NMR data are also reported for the first time.