Related Experiment Video
Updated: Feb 2, 2026
08:34
A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening
Published on: October 16, 2015
10.5K
A New Neolignan from Panicum turgidum
Natural Product Communications
|November 20, 2018
Summary
Researchers isolated a new neolignan, paniculignan, and a known lignan from Panicum turgidum. Structural elucidation involved advanced spectroscopic techniques and analysis of relative configuration.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Panicum turgidum is a plant species with potential for novel compound discovery.
- Lignans and neolignans are classes of natural products with diverse biological activities.
Purpose of the Study:
- To isolate and characterize novel and known compounds from Panicum turgidum.
- To elucidate the chemical structure and relative configuration of a new neolignan.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation of paniculignan (1) utilizing 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy and High-Resolution Electrospray Ionization Mass Spectrometry (HR-ESI-MS).
- Determination of relative configuration using Circular Dichroism (CD) spectroscopy, optical rotation, and Nuclear Overhauser Effect Spectroscopy (NOESY) correlations.
Main Results:
- A new neolignan, named paniculignan (1), was successfully isolated.
- A known lignan, tetracentronside B (2), was also identified.
- The structure and relative configuration of paniculignan were comprehensively determined.
Conclusions:
- Panicum turgidum is a source of structurally interesting lignans and neolignans.
- Paniculignan represents a novel chemical entity with potential for further investigation.
- The applied spectroscopic methods were effective for structural characterization of natural products.
