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[On the antipyretic effect of paracetamol. Clinical investigation with two different forms of application (author's
Insights
Paracetamol syrup and suppositories show similar fever reduction in children. Combining paracetamol with doxylamine succinate reduced its effectiveness and did not improve hyperactivity.
Area of Science:
- Pediatrics
- Pharmacology
Background:
- Febrile conditions are common in children.
- Paracetamol (N-acetyl-p-aminophenol) is a widely used antipyretic.
- Different formulations and combinations exist for pediatric use.
Purpose of the Study:
- To compare the antipyretic efficacy of paracetamol syrup versus suppositories.
- To evaluate the effect of combining paracetamol syrup with doxylamine succinate on fever and psychomotor activity.
Main Methods:
- 144 children aged 15 days to 12 years with febrile conditions were treated.
- Differentiated single doses of paracetamol in syrup and suppository forms were administered.
- A combination of paracetamol syrup with doxylamine succinate was also tested.
- Antipyretic effects and psychomotor activity were monitored over four hours.
Main Results:
- Paracetamol syrup demonstrated comparable antipyretic effects to paracetamol suppositories at reduced doses.
- The combination of paracetamol with doxylamine succinate showed reduced antipyretic efficacy.
- The combination did not improve psychomotor hyperactivity in febrile children.
Conclusions:
- Paracetamol syrup is an effective alternative to suppositories for reducing fever in children.
- Combining paracetamol with doxylamine succinate may diminish its antipyretic properties.
- Further investigation into rectal dosage schemes and combining paracetamol with sedatives is warranted.
Abstract:
144 children, aged between 15 days and 12 years, suffering from febrile condition of various etiology, were treated with differentiated single doses of paracetamol (N-acetyl-p-aminophenol) in form of syrup, suppositories and a combination of syrup with the antihistamine doxylaminsuccinate. During investigation periods of four hours, applying reduced doses, the syrup application showed the same antipyretic effects as those obtained with paracetamol suppositories. When administering the combination with doxylaminsuccinate, the antipyretic effect was reduced and the psychomotoric superactivity did not improve. A control of the actual rectal dosage scheme for repetitive applications is recommended and the combination of paracetamol with sedatives is to be discussed.