Related Experiment Video
Updated: Feb 2, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Web-Based Contingency Management for Adolescent Tobacco Smokers: A Clinical Trial.
Arit Harvanko1, Stacey Slone2, Brent Shelton3
1Center for Tobacco Research and Education, University of California, San Francisco, San Francisco, CA.
Remote contingency management shows promise for adolescent smoking cessation, reducing carbon monoxide levels during treatment. However, poor adherence and follow-up efficacy highlight the need for program improvements.
Area of Science:
- Behavioral Science
- Public Health
- Addiction Medicine
Background:
- Adolescence is a critical period for smoking initiation, with most tobacco users starting during this phase.
- Contingency management (CM) has shown potential for adolescent smoking cessation, but its long-term effectiveness after removing incentives is unclear.
- This study investigated a remote CM intervention for adolescent smokers who were not actively seeking treatment.
Purpose of the Study:
- To evaluate the feasibility and efficacy of a remote contingency management intervention for adolescent smoking cessation.
- To assess the impact of reinforced CO monitoring on smoking behavior and biochemical verification.
Main Methods:
- A randomized trial involving 127 adolescent smokers who submitted breath carbon monoxide (CO) levels three times daily for 42 days.
- The active group (n=63) received reinforcement for timely CO submissions below a criterion, while the control group (n=64) was reinforced only for timely submissions.
- Self-reported smoking and urinary cotinine levels were collected to verify smoking status.
Main Results:
- The active CM group demonstrated greater within-group reductions in CO levels compared to the control group during the intervention period.
- Significantly less smoking was self-reported by the active group during treatment, but this difference did not persist at follow-up.
- No significant differences in urinary cotinine levels were observed between groups.
- Overall treatment adherence was low, with less than 51% of possible CO samples submitted in either group.
Conclusions:
- Remote CM is feasible for adolescent smoking cessation, with within-group CO reductions observed.
- Poor treatment adherence and low follow-up efficacy were significant limitations.
- Future research must focus on enhancing adherence and improving long-term outcomes for adolescent smoking cessation programs.
Related Concept Videos
Clinical Trials
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview
Contingency Table
Statistical Software for Data Analysis and Clinical Trials
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...

