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Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
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Genomic updates in understanding PTSD.

Sumeet Sharma1, Kerry J Ressler2

  • 1Neuroscience Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States; McLean Hospital, Division of Depression and Anxiety, Belmont, MA, United States.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|November 20, 2018
PubMed
Summary
This summary is machine-generated.

Genetics play a significant role in post-traumatic stress disorder (PTSD) risk, accounting for up to 50% of heritability. This review explores genetic pathways influencing PTSD development and resilience after trauma.

Keywords:
AnxietyDepressionEpigeneticGene-by-environment interactionPTSDStressTrauma

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Area of Science:

  • Genetics
  • Psychiatry
  • Trauma Studies

Background:

  • Post-traumatic stress disorder (PTSD) has a significant heritable component, with estimates up to 40-50% from twin and genetic studies.
  • Specific genetic mechanisms underlying PTSD risk and resilience remain largely unknown.

Purpose of the Study:

  • To review recent findings from large-scale genetic studies on PTSD.
  • To elucidate the gene pathways and mechanisms influencing PTSD development and recovery.

Main Methods:

  • Review of large-scale Genome-wide association studies (GWAS).
  • Analysis of other genetic approaches investigating PTSD mechanisms.

Main Results:

  • Heritability estimates for PTSD risk range from 40-50%.
  • Specific genetic pathways mediating risk and resilience are under investigation.

Conclusions:

  • Genetics significantly influences an individual's susceptibility and resilience to PTSD.
  • Further research into genetic mechanisms is crucial for understanding and treating PTSD.