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A Portable Smartphone-Based Sensing System Using a 3D-Printed Chip for On-Site Biochemical Assays
1Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310058, China. wfy@zju.edu.cn.
Sensors (Basel, Switzerland)
|November 21, 2018
Summary
A new portable system uses 3D-printed chips and smartphone apps for easy biochemical sensing. This overcomes limitations of paper-based methods, enabling flexible detection of various substances like pesticides and in fruit juice.
Area of Science:
- Analytical Chemistry
- Biochemical Sensing
- Microfluidics
Background:
- Smartphone-based chromogenic sensing with paper microfluidics is vital for biochemical assays.
- Existing methods face challenges including complex fabrication, unclear hydrophobic boundaries, unstable signal capture, and limited app adaptability.
Purpose of the Study:
- To develop a portable smartphone-based sensing system using a 3D-printed chip to address limitations of current paper-based microfluidic technologies.
- To enhance signal capture stability and create a flexible, reprogrammable app for diverse biochemical assays.
Main Methods:
- A 3D-printed imaging platform was designed to minimize sensing errors during signal acquisition.
- A novel signal processing strategy was implemented within downloadable smartphone applications.
- The system was validated through the detection of organophosphorus pesticides and multi-assay analysis of fruit juice.
Main Results:
- The 3D-printed system demonstrated excellent sensing performance for both specific analyte detection and multi-assay applications.
- The system allows for the selection of optimal color channels for signal analysis based on the target analyte.
- Calibration equations can be directly configured via the user interface, eliminating the need for reprogramming.
Conclusions:
- The developed portable sensing system offers a novel and flexible methodology for smartphone-based biochemical sensing.
- This approach overcomes key drawbacks of traditional paper-based microfluidic chips.
- The system's adaptability makes it suitable for a wide range of future biochemical assay applications.
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