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The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
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Updated: Feb 2, 2026

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Thermoregulation and nausea.

Eugene Nalivaiko1

  • 1School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.

Handbook of Clinical Neurology
|November 21, 2018
PubMed
Summary
This summary is machine-generated.

Motion sickness symptoms like nausea and sweating are linked to disrupted body temperature regulation, causing hypothermia. This study explores the physiological mechanisms behind this thermoregulatory response in humans and animals.

Keywords:
hypothermiamotion sicknessnauseaskin blood flowsweatingthermogenesisthermoregulation

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Area of Science:

  • Physiology
  • Thermoregulation
  • Motion Sickness

Background:

  • Motion sickness symptoms such as pallor, nausea, vomiting, and sweating are well-documented.
  • These symptoms are increasingly recognized as indicators of significantly disturbed thermoregulation.
  • Hypothermia during seasickness was first observed approximately 150 years ago, with detailed research emerging in the last two decades.

Purpose of the Study:

  • To present and discuss existing data on the link between motion sickness and thermoregulation.
  • To explore the physiological mechanisms underlying motion sickness-induced hypothermia.
  • To investigate the phylogenetic breadth of this phenomenon.

Main Methods:

  • Review of existing human and animal experimental data.
  • Confirmation of motion sickness-induced hypothermia in humans, rats, musk shrews, and mice.
  • Analysis of physiological responses including cutaneous vasodilation, sweating, and thermogenesis.

Main Results:

  • Motion sickness-induced hypothermia is a phylogenetically conserved response.
  • Physiological mechanisms involve increased heat loss (cutaneous vasodilation, sweating) and reduced heat production (thermogenesis).
  • These coordinated responses aim to decrease core body temperature.

Conclusions:

  • Motion sickness triggers a coordinated physiological response to reduce body temperature.
  • The observed hypothermia is a key, though often overlooked, aspect of motion sickness.
  • Further hypotheses are presented regarding the evolutionary and functional significance of this thermoregulatory response.