Alcohol Use Disorders in Alcoholic Liver Disease
Jessica L Mellinger1, Gerald Scott Winder2
1Division of Gastroenterology and Hepatology, Michigan Medicine, 1500 East Medical Center Drive, SPC 5334, Ann Arbor, MI 48109, USA.
Clinics in Liver Disease
|November 21, 2018
Summary
Alcohol use disorder (AUD) is a key factor in alcoholic liver disease (ALD). Effective AUD treatment involves a patient-provider alliance and tailored therapies for better outcomes.
Area of Science:
- Hepatology
- Addiction Medicine
- Clinical Psychology
Background:
- Alcohol use disorder (AUD) is intrinsically linked to the pathophysiology of alcoholic liver disease (ALD).
- Effective management of ALD necessitates addressing co-occurring AUD.
- A strong patient-provider alliance is crucial for optimal treatment outcomes.
Purpose of the Study:
- To outline the diagnostic approaches for AUD in patients with ALD.
- To review the advantages and limitations of alcohol biomarkers in AUD diagnosis.
- To present a comprehensive overview of available AUD treatment modalities for ALD patients.
Main Methods:
- Diagnostic methods include thorough patient history, physical examination, validated screening questionnaires, and objective alcohol biomarkers.
- Evaluation of the clinical utility and limitations of various alcohol biomarkers.
- Review of evidence-based treatment strategies for AUD.
Main Results:
- AUD diagnosis relies on a combination of clinical assessment and biomarker data.
- Alcohol biomarkers offer objective measures but require careful interpretation due to potential confounding factors.
- A wide array of effective, individualized treatment options exist for AUD.
Conclusions:
- Integrated, multidisciplinary care is essential for managing patients with ALD and AUD.
- Accurate AUD diagnosis using diverse methods, including biomarkers, is critical.
- Personalized treatment plans incorporating various therapeutic modalities lead to improved patient outcomes in ALD.
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