Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecular Shape and Polarity03:37

Molecular Shape and Polarity

75.7K
Dipole Moment of a Molecule
75.7K
VSEPR Theory and the Basic Shapes02:52

VSEPR Theory and the Basic Shapes

84.8K
Overview of VSEPR Theory
84.8K
Molecular Shapes01:18

Molecular Shapes

62.0K
Molecules have characteristic shapes that are crucial for their function. The arrangement of various electron groups around the central atom dictates their molecular geometry. Electron pairs in the valence shell of a central atom will adopt an arrangement that minimizes repulsions between the electron pairs by maximizing the distance between them. The valence electrons form either bonding pairs, located primarily between bonded atoms, or lone pairs.
Two regions of electron density in a diatomic...
62.0K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.1K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.1K
First Derivatives and the Shape of a Graph01:22

First Derivatives and the Shape of a Graph

81
In calculus, the concept of the first derivative plays a crucial role in understanding the behavior of a function over its domain. The first derivative, denoted as f’(x), provides insight into how a function changes at any given point, much like a cyclist adjusting speed along a winding trail. By analyzing the first derivative, mathematicians can determine where a function is increasing, decreasing, or reaching critical points.The first derivative provides a precise method for classifying...
81
Second Derivatives and the Shape of a Graph01:29

Second Derivatives and the Shape of a Graph

106
The second derivative of a function provides essential information about a graph's curvature and how it changes over an interval. It helps determine whether a function is concave upward or concave downward and identifies points where the curvature changes. These properties are fundamental in analyzing real-world scenarios, such as changes in road elevation, population growth, and economic trends.A function f(x) is considered concave upward on an interval if its graph lies above all its tangent...
106

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Predictive Model for Coupling Cell Division Orientation to Tissue Mechanics During Epithelial Morphogenesis.

bioRxiv : the preprint server for biology·2026
Same author

Rigidity and Mechanical Response in Biological Structures.

Annual review of biophysics·2026
Same author

Cell divisions both challenge and refine tissue boundaries in the Drosophila embryo.

Development (Cambridge, England)·2026
Same author

Microglial MyD88-dependent signaling influences extracellular matrix development and interneuron maturation in the hippocampus.

bioRxiv : the preprint server for biology·2025
Same author

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle.

Developmental dynamics : an official publication of the American Association of Anatomists·2025
Same author

Dynamic forces drive cell and organ morphology changes during embryonic development.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

Anisotropic unbinding and location-dependent hovering of a kinesin motor head over microtubule.

Biophysical journal·2026
Same journal

Kinesin-5/Cut7 C-terminal tail phosphorylation influence on motor regulation through multi-scale molecular modeling.

Biophysical journal·2026
Same journal

Dynamic conformations of fluorophores on self-labeling protein tags.

Biophysical journal·2026
Same journal

Different actions of RyR2 open and closed channel block explained by a multiscale Ca<sup>2+</sup> release model.

Biophysical journal·2026
Same journal

Membrane Environment Sets the Functional pK<sub>a</sub> of Ionizable Lipids.

Biophysical journal·2026
Same journal

Distinguishable spreading dynamics in microbial communities.

Biophysical journal·2026
See all related articles

Related Experiment Video

Updated: Feb 2, 2026

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines
08:50

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

Published on: April 18, 2025

949

Tissue Flow Induces Cell Shape Changes During Organogenesis.

Gonca Erdemci-Tandogan1, Madeline J Clark2, Jeffrey D Amack2

  • 1Department of Physics, Syracuse University, Syracuse, New York.

Biophysical Journal
|November 21, 2018
PubMed
Summary
This summary is machine-generated.

Fluid-like drag forces from surrounding tissue motion drive embryonic cell shape changes. This study on zebrafish Kupffer's vesicle (KV) reveals how these forces influence organ development and function.

More Related Videos

Author Spotlight: Insight into the Current Experimental Avian Skin Explant Methodologies
09:30

Author Spotlight: Insight into the Current Experimental Avian Skin Explant Methodologies

Published on: September 15, 2023

1.6K
Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair
05:05

Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair

Published on: June 9, 2020

6.0K

Related Experiment Videos

Last Updated: Feb 2, 2026

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines
08:50

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

Published on: April 18, 2025

949
Author Spotlight: Insight into the Current Experimental Avian Skin Explant Methodologies
09:30

Author Spotlight: Insight into the Current Experimental Avian Skin Explant Methodologies

Published on: September 15, 2023

1.6K
Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair
05:05

Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair

Published on: June 9, 2020

6.0K

Area of Science:

  • Developmental biology
  • Biophysics
  • Cell biology

Background:

  • Cell shape changes are crucial for embryonic organ formation.
  • Mechanisms regulating these shape changes are often poorly understood.
  • The zebrafish Kupffer's vesicle (KV) provides a model for studying these processes.

Purpose of the Study:

  • To investigate the role of fluid-like drag forces in regulating cell shape changes during embryonic development.
  • To test the hypothesis that organ motion through surrounding tissue generates forces driving structural changes.
  • To understand the specific mechanisms behind cell shape alterations in the zebrafish KV.

Main Methods:

  • Experimental observation of zebrafish Kupffer's vesicle (KV) development.
  • Mathematical modeling of cell shapes incorporating tissue rheology and cell motility.
  • Constraining model parameters with rheological data and KV speed measurements.

Main Results:

  • Drag forces generated by surrounding cell dynamics can sufficiently drive KV cell shape changes.
  • These forces may act independently or in conjunction with known mechanisms.
  • Region-specific cell shape changes (anterior: long/thin; posterior: short/squat) were modeled.

Conclusions:

  • Dynamic drag forces represent a significant, often overlooked, factor in embryonic cell shape regulation.
  • This mechanism could be broadly applicable to cell shape changes in embryonic development and beyond.
  • Findings offer new insights into the biophysical forces shaping developing organs.