Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The minimum clinically important difference (MCID) for a falls intervention in Parkinson's: A delphi study.

Emily J Henderson1, Gemma S Morgan2, Jigisha Amin3

  • 1Department of Population Health Sciences, Bristol Medical School, University of Bristol, 39 Whatley Road, Bristol, BS8 2PS, United Kingdom; Royal United Hospitals NHS Foundation Trust Bath, BA1 3NG, United Kingdom.

Parkinsonism & Related Disorders
|November 21, 2018
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictive accuracy of gait speed for falls: An individual participant data meta-analysis.

Ageing research reviews·2026
Same author

Mind the Gap: Predictors of Osteoporosis Treatment Following Fragility Fracture in Parkinsonism.

Movement disorders clinical practice·2026
Same author

Situational triggers of urinary urgency episodes in Parkinson's disease.

Autonomic neuroscience : basic & clinical·2026
Same author

Patient activation among patients with Parkinsonism and informal caregivers: results from the PRIME-UK cross-sectional study.

European geriatric medicine·2026
Same author

Optimisation of a sexual health and healthy relationships intervention for Further Education in England and Wales (SaFE).

Public health research (Southampton, England)·2025
Same author

The interrelationship of frailty, multimorbidity and disability in Parkinson's disease: PRIME-UK cross-sectional study.

The Journal of frailty & aging·2025

Experts determined that a 25% reduction in fall rates is clinically meaningful for Parkinson's disease patients. This finding helps calculate sample sizes for future clinical trials investigating fall prevention interventions.

Area of Science:

  • Neurology
  • Clinical Trials
  • Geriatrics

Background:

  • Falls are a significant challenge for individuals with Parkinson's disease (PD).
  • Interventions to reduce fall risk are crucial for improving patient quality of life.
  • Cholinesterase inhibitor (ChEi) drugs are a potential therapeutic avenue for fall reduction in PD.

Purpose of the Study:

  • To establish the minimum clinically important difference (MCID) for fall rates in Parkinson's disease.
  • To provide an evidence-based effect estimate for sample size calculations in future clinical trials.

Main Methods:

  • A Delphi study was conducted with a panel of Parkinson's disease experts.
  • Expert opinions were gathered and refined through multiple rounds to reach a consensus.
Keywords:
Cholinesterase inhibitorsDelphi techniqueFallsParkinson diseaseSample size

Related Experiment Videos

  • The study involved 780 clinicians with an average of 14 years of experience in PD care.

    • Main Results:

    • The median MCID for fall rates was established at 25% after the first round of the Delphi study.
    • This 25% reduction equates to preventing an average of 5 falls per year per patient.
    • Consensus was strengthened in the second round, confirming the 25% MCID with a narrower interquartile range of 20%-25%.

    Conclusions:

    • An expert consensus identified a 25% relative reduction in fall rate as clinically meaningful for Parkinson's disease.
    • This established MCID is vital for designing future clinical trials and determining appropriate sample sizes.
    • The findings support the development of targeted interventions to mitigate fall risk in PD patients.