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Related Experiment Videos

Exercise-induced asthma.

C W Bierman1

  • 1University of Washington School of Medicine, Seattle 98105.

New England and Regional Allergy Proceedings
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

Exercise-induced asthma (EIA) is manageable with pre-exercise albuterol or terbutaline. Other medications like theophylline and cromolyn show variable effectiveness, while others are less effective alone for EIA prevention.

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Area of Science:

  • Pulmonology
  • Exercise Physiology
  • Pharmacology

Background:

  • Exercise-induced asthma (EIA) has a long history, but recent decades have advanced its understanding.
  • Ongoing debates exist regarding EIA's causes and the mechanisms of various bronchial challenges.
  • The occurrence and importance of late-phase reactions in EIA require further investigation.

Purpose of the Study:

  • To review the current understanding of exercise-induced asthma.
  • To discuss standardized testing and pharmacologic management strategies for EIA.
  • To clarify the efficacy of different medications in preventing and managing EIA.

Main Methods:

  • Literature review of studies on exercise-induced asthma characteristics, testing, and treatment.
  • Analysis of pharmacologic interventions, including adrenergic agents, theophylline, cromolyn, and others.

Related Experiment Videos

  • Evaluation of the effectiveness of various agents in preventing EIA.

    • Main Results:

    • Aerosolized adrenergic agents (albuterol, terbutaline) are generally effective in preventing EIA when used before exercise.
    • Theophylline and cromolyn sodium demonstrate variable effectiveness among individuals.
    • Other agents like antihistamines, ipratropium bromide, calcium channel blockers, and corticosteroids show limited efficacy alone but can be adjuncts.

    Conclusions:

    • Pre-exercise administration of inhaled beta-2 agonists is a primary strategy for EIA prevention.
    • Medication choice for EIA management should consider individual variability and potential synergistic effects.
    • Further research is needed to resolve controversies regarding EIA etiology and late-phase reactions.