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Exercise-induced anaphylaxis.

A L Sheffer1

  • 1Harvard Medical School, Boston, Massachusetts.

New England and Regional Allergy Proceedings
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

Anaphylaxis, a severe allergic reaction, involves skin, respiratory, and cardiovascular changes. Exercise-induced anaphylaxis shows mast cell degranulation similar to other allergic reactions, requiring prompt treatment and avoidance of triggers like aspirin before exercise.

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Area of Science:

  • Allergy and Immunology
  • Pathology
  • Cell Biology

Background:

  • Anaphylaxis is a critical allergic reaction with diverse clinical manifestations.
  • It affects multiple organ systems, including skin, respiratory, and cardiovascular systems.
  • Exercise-induced anaphylaxis presents unique challenges in diagnosis and management.

Purpose of the Study:

  • To investigate the ultrastructural changes in mast cells during exercise-induced anaphylaxis.
  • To compare these changes with those observed in other allergic reactions.
  • To understand the cellular mechanisms underlying exercise-induced anaphylaxis.

Main Methods:

  • Ultrastructural analysis of skin biopsies.
  • Comparison of biopsies taken before and immediately after exercise.

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  • Examination of mast cell granule morphology and membrane interactions.

    • Main Results:

    • Skin biopsies from exercise-induced anaphylaxis patients showed mast cell degranulation.
    • Observed changes included granule enlargement and content solubilization.
    • These alterations were similar to those seen after immunologic challenge of pulmonary mast cells.

    Conclusions:

    • Exercise-induced anaphylaxis involves mast cell degranulation, similar to other allergic responses.
    • Prompt recognition and early therapy are crucial for managing anaphylaxis.
    • Patients should avoid specific triggers, like aspirin, before exercise.