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Microsponge: An emerging drug delivery strategy.

Gautam Singhvi1, Prachi Manchanda1, Neha Hans1

  • 1Department of Pharmacy, Birla Institute of Technology & Science (BITS), Pilani, Rajasthan, India.

Drug Development Research
|November 21, 2018
PubMed
Summary

Microsponges are innovative drug delivery systems that improve drug efficacy and reduce side effects. This study details their preparation, characterization, and applications in enhanced transdermal delivery.

Keywords:
drug deliverymicrospongesquasi-emulsion diffusion solvent methodsuspension polymerization

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Microsponges are spherical particles (5-300 μm) composed of smaller spheres.
  • They offer efficient drug delivery, improved stability, modified release profiles, and minimized side effects.

Purpose of the Study:

  • To provide a comprehensive overview of the microsponge drug delivery system.
  • To elucidate the preparation, characterization, and advantages of microsponges.

Main Methods:

  • Preparation techniques include liquid-liquid suspension polymerization and quasi-emulsion solvent diffusion.
  • Characterization involves particle-size measurement, porosity, morphology, true density, rheological properties, and dissolution studies.

Main Results:

  • Microsponge drug delivery systems reduce transdermal invasion while prolonging drug presence on the skin.
  • These systems enable efficient drug delivery at lower doses.

Conclusions:

  • Microsponges represent a versatile platform for advanced drug delivery.
  • This detailed study serves as a valuable resource for understanding microsponge technology.