Hypothermia as a risk factor for Alzheimer disease
Maria Camila Almeida1, Daniel Carneiro Carrettiero1
1Natural and Human Sciences Center, Federal University of ABC, São Bernardo do Campo, SP, Brazil.
Handbook of Clinical Neurology
|November 22, 2018
Summary
Aging impairs body temperature regulation, potentially increasing Alzheimer disease (AD) risk. This study examines how hypothermia, a common aging issue, impacts AD
Area of Science:
- Neuroscience
- Gerontology
- Pathology
Background:
- Alzheimer disease (AD) is the leading cause of age-related dementia, characterized by progressive neurodegeneration.
- Aging is the primary risk factor for AD, with most cases occurring in individuals 65 and older.
- The link between aging and AD pathogenesis, particularly impaired thermal homeostasis, is not fully understood.
Purpose of the Study:
- To assess clinical and biochemical evidence linking hypothermia to Alzheimer disease development.
- To investigate the impact of hypothermia on key AD pathological hallmarks.
Main Methods:
- Review of clinical evidence on hypothermia as an AD risk factor.
- Analysis of biochemical data concerning hypothermia's effects.
- Examination of hypothermia's influence on amyloid-beta plaque and tau tangle pathology.
Main Results:
- Impaired thermal homeostasis in aging may contribute to metabolic changes associated with AD.
- Hypothermia is implicated as a potential risk factor for Alzheimer disease.
- Hypothermia affects the accumulation of amyloid-beta plaques and neurofibrillary tangles in AD.
Conclusions:
- Impaired thermoregulation during aging could be a significant factor in Alzheimer disease development.
- Hypothermia's impact on AD pathology warrants further investigation for therapeutic strategies.
- Understanding the aging-hypothermia-AD link may offer new insights into dementia prevention and treatment.
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