Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IgM's exit route.

Anne Reversat1, Michael Sixt2

  • 1Institute of Science and Technology Austria, Klosterneuburg, Austria.

The Journal of Experimental Medicine
|November 22, 2018
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mass Cytometry-Based Approach for the Investigation of Stimulator of Interferon Genes Pathway.

European journal of immunology·2025
Same author

Migrating immune cells globally coordinate protrusive forces.

Nature immunology·2025
Same author

Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis.

The Journal of experimental medicine·2025
Same author

Nuclear squeezing wakes up dendritic cells.

Nature immunology·2024
Same author

Lift-out cryo-FIBSEM and cryo-ET reveal the ultrastructural landscape of extracellular matrix.

The Journal of cell biology·2024
Same author

CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration.

Science immunology·2023
Same journal

Retraction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.

The Journal of experimental medicine·2026
Same journal

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.

The Journal of experimental medicine·2026
Same journal

Flawed translation triggers oncogenic B-T cell communication.

The Journal of experimental medicine·2026
Same journal

Correction: LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated.

The Journal of experimental medicine·2026
Same journal

Mechanobiology of inflammation: Pulling the strings of innate immunity.

The Journal of experimental medicine·2026
Same journal

Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis.

The Journal of experimental medicine·2026
See all related articles

Freshly activated plasmablasts secrete IgM, which then exits lymph nodes through the fibroblastic reticular cell conduit. This pathway optimizes immune effector distribution throughout the body.

Area of Science:

  • Immunology
  • Cell Biology
  • Anatomy

Background:

  • Lymphatic organs are crucial for immune responses.
  • The stromal compartment plays a key role in immune cell trafficking.
  • Understanding immune effector distribution is vital for effective immunity.

Purpose of the Study:

  • To investigate the route of IgM transport from lymph nodes.
  • To elucidate the role of the fibroblastic reticular cell conduit in immune effector dissemination.
  • To understand how lymphatic organ architecture facilitates systemic immunity.

Main Methods:

  • The study likely involved tracking IgM secretion and movement within lymph nodes.
  • Analysis of lymph node microarchitecture, particularly the fibroblastic reticular cell conduit.

Related Experiment Videos

  • Immunohistochemistry or imaging techniques may have been employed.

    • Main Results:

    • Newly secreted IgM by activated plasmablasts exits the lymph node.
    • The fibroblastic reticular cell conduit serves as the primary route for IgM egress.
    • Lymphatic stromal architecture is optimized for the systemic distribution of immune effectors.

    Conclusions:

    • The fibroblastic reticular cell conduit is a critical pathway for IgM transport out of lymph nodes.
    • Lymphatic stromal components actively facilitate the systemic spread of immune molecules.
    • This mechanism ensures efficient immune surveillance and response.