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Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging
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Motion-resolved quantitative phase imaging.

Michael Kellman1, Michael Chen1, Zachary F Phillips2

  • 1Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720, USA.

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|November 22, 2018
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Summary
This summary is machine-generated.

Quantitative phase imaging using Differential Phase Contrast (DPC) can now capture fast-moving samples. A new computational method corrects for sample motion, enabling single-shot imaging and high-speed dynamic visualization.

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Area of Science:

  • Biomedical optics
  • Computational imaging
  • Microscopy

Background:

  • Quantitative phase imaging (QPI) offers label-free contrast.
  • Differential Phase Contrast (DPC) QPI requires multiple measurements, limiting temporal resolution.
  • Imaging fast-moving biological samples is challenging due to motion blur.

Purpose of the Study:

  • To improve the temporal resolution of DPC imaging.
  • To enable high-framerate imaging of dynamic biological processes.
  • To correct for non-rigid sample motion during DPC acquisition.

Main Methods:

  • Developed a computational approach to model and correct for non-rigid sample motion.
  • Incorporated a simultaneously-acquired color-multiplexed reference signal.
  • Enabled non-rigid registration of measurements prior to phase retrieval.

Main Results:

  • Achieved single-shot temporal resolution for DPC imaging.
  • Successfully reduced motion blur in fast-moving live biological samples.
  • Enabled imaging of sample dynamics at the sensor's native framerate.

Conclusions:

  • The presented computational method significantly enhances DPC imaging capabilities.
  • This technique opens new possibilities for studying dynamic biological phenomena.
  • High-speed quantitative phase imaging is now feasible for previously intractable samples.