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A Rapid Method for Multispectral Fluorescence Imaging of Frozen Tissue Sections
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Low-cost compact multispectral spatial frequency domain imaging prototype for tissue characterization.

Mohsen Erfanzadeh1, Sreyankar Nandy2, Patrick D Kumavor1

  • 1Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.

Biomedical Optics Express
|November 22, 2018
PubMed
Summary
This summary is machine-generated.

We developed a low-cost, compact multispectral spatial frequency domain imaging (sFDI) probe. This device can reconstruct optical properties and shows potential for biological tissue imaging.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging Technology
  • Optical Physics

Background:

  • Spatial Frequency Domain Imaging (sFDI) offers non-invasive optical property measurement.
  • Existing sFDI systems can be costly and bulky.
  • A need exists for compact, affordable, and versatile sFDI instrumentation.

Purpose of the Study:

  • To develop and validate a low-cost, compact, multispectral sFDI prototype.
  • To assess the probe's capability in reconstructing absorption and reduced scattering coefficients.
  • To evaluate the probe's potential for imaging biological tissues.

Main Methods:

  • A custom 3D-printed probe housing 9 LEDs (660-950 nm), motors, and optics was designed.
  • Sinusoidal patterns were projected for sFDI measurements.
  • Absorption and reduced scattering coefficients were reconstructed using tissue-mimicking phantoms.
  • Ex vivo human ovarian tissue was imaged to assess biological applicability.

Main Results:

  • The prototype successfully integrated illumination and detection components into a compact design.
  • Reconstruction of optical properties was achieved using tissue-mimicking phantoms.
  • Preliminary imaging of ex vivo human ovarian tissue demonstrated the probe's potential for biological applications.

Conclusions:

  • A low-cost, compact, multispectral sFDI probe was successfully developed.
  • The prototype is capable of reconstructing optical properties of phantoms.
  • The developed probe shows promise for future in vivo and ex vivo biological tissue imaging.