Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heritability01:06

Heritability

665
Heritability is a statistical concept that measures the degree to which genetic differences among individuals contribute to trait variations within a population. It is a fundamental idea in genetics, often prone to misinterpretation. Heritability is expressed as a percentage, reflecting the proportion of variation in a specific trait across a population that can be linked to genetic differences. However, it's important to understand that heritability does not determine how "genetic"...
665
Trait and State Self-Esteem02:08

Trait and State Self-Esteem

11.5K
The term self-esteem is often used generically, to refer to how people feel about themselves. However, according to research, there are three distinct constructs that should not be used interchangeably (Brown & Marshall, 2006). 
11.5K
Polygenic Traits01:18

Polygenic Traits

69.1K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
69.1K
Multiple Allele Traits01:49

Multiple Allele Traits

38.1K
The Concept of Multiple Allelism
38.1K
Traits and States01:17

Traits and States

557
Personality traits represent consistent patterns in behavior, thoughts, and emotions, reflecting an individual's tendencies across various situations. For example, extraversion, a well-known trait, manifests in individuals as talkative, energetic, and enthusiastic behaviors. These traits are stable over time, offering a reliable framework for predicting how people might act in different contexts. However, they do not define every moment of an individual's life. In contrast to traits,...
557
X-linked Traits01:19

X-linked Traits

58.6K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
58.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of adjuvant somatostatin analogue therapy with disease-free survival in patients with gastroenteropancreatic neuroendocrine tumours: a Chinese multi-institutional propensity score matched and weighted analysis (CASSANET-GEP).

BMC medicine·2026
Same author

Integrating Genetics Into Nephrology Practice: A New Standard of Care?

Advances in kidney disease and health·2026
Same author

Using ddPCR to Identify Large Deletions of Complement Factor H-Related Genes in Atypical Hemolytic Uremic Syndrome.

The journal of applied laboratory medicine·2026
Same author

4-Hydroxychalcone Exert the Anti-cancer Potential in Colorectal Cancer Through Targeting CDK6.

Biological procedures online·2026
Same author

Diagnostic Yield of Exome Sequencing after Negative or Inconclusive Kidney Genes Panel Testing.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

The Significance of Fibroblast Growth Factor 23 and 24,25-Dihydroxyvitamin D in Dent Disease Type 1.

Clinical journal of the American Society of Nephrology : CJASN·2026

Related Experiment Video

Updated: Feb 2, 2026

Determining the Contribution of the Energy Systems During Exercise
11:15

Determining the Contribution of the Energy Systems During Exercise

Published on: March 20, 2012

42.4K

Heritable traits that contribute to nephrolithiasis.

John C Lieske1,2, Xiangling Wang3

  • 1Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55901, USA. Lieske.John@mayo.edu.

Urolithiasis
|November 22, 2018
PubMed
Summary

Urinary stones often run in families, with genetics strongly influencing calcium excretion. Research suggests heritability may also impact other stone risk factors and even environmental influences like diet and thirst.

Keywords:
CalciumDietGeneticsUrinary stone disease

More Related Videos

Relating Stomatal Conductance to Leaf Functional Traits
11:09

Relating Stomatal Conductance to Leaf Functional Traits

Published on: October 12, 2015

19.7K
Environmentally Induced Heritable Changes in Flax
08:10

Environmentally Induced Heritable Changes in Flax

Published on: January 26, 2011

10.6K

Related Experiment Videos

Last Updated: Feb 2, 2026

Determining the Contribution of the Energy Systems During Exercise
11:15

Determining the Contribution of the Energy Systems During Exercise

Published on: March 20, 2012

42.4K
Relating Stomatal Conductance to Leaf Functional Traits
11:09

Relating Stomatal Conductance to Leaf Functional Traits

Published on: October 12, 2015

19.7K
Environmentally Induced Heritable Changes in Flax
08:10

Environmentally Induced Heritable Changes in Flax

Published on: January 26, 2011

10.6K

Area of Science:

  • Nephrology
  • Genetics
  • Metabolic Disorders

Background:

  • Urinary stones (calculi) exhibit familial clustering, suggesting a genetic predisposition.
  • Heritability of urinary calcium excretion is a well-established risk factor for stone formation.
  • Emerging evidence indicates potential genetic components in other urinary stone risk factors.

Purpose of the Study:

  • To explore the heritable components of various urinary stone risk factors.
  • To investigate the genetic influence on urinary pH, citrate, magnesium, and vitamin D levels.
  • To examine the potential genetic basis for environmental factors like dietary intake and thirst in stone pathogenesis.

Main Methods:

  • Review of recent genetic and epidemiological studies on urinary stone disease.
  • Analysis of heritability estimates for key urinary stone risk factors.
  • Comparative assessment of genetic versus environmental contributions to stone formation.

Main Results:

  • Urinary calcium excretion shows the strongest evidence for heritability.
  • Urinary pH, citrate, magnesium excretion, and vitamin D concentration may also have heritable components.
  • Factors traditionally viewed as environmental, such as diet and thirst, might also be influenced by genetics.

Conclusions:

  • Genetics likely plays a significant role in the development of urinary stones.
  • Further research may uncover a stronger genetic contribution to urinary stone pathogenesis than currently recognized.
  • Understanding the genetic basis of stone risk factors is crucial for personalized prevention strategies.