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Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling
Published on: February 12, 2019
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Tissue-informed engineering strategies for modeling human pulmonary diseases.
Kolene E Bailey1, Michael L Floren2,3,4, Tyler J D'Ovidio1
1Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
American Journal of Physiology. Lung Cellular and Molecular Physiology
|November 22, 2018
Summary
Engineering strategies using precision biomaterials and advanced biomanufacturing can improve disease models for chronic pulmonary diseases like idiopathic pulmonary fibrosis (IPF). This approach aims to accelerate the development of personalized therapies for these conditions.
Area of Science:
- Pulmonary Medicine and Biomedical Engineering
- Biomaterials and Biomanufacturing
- Extracellular Matrix and Tissue Mechanics
Background:
- Chronic pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), pulmonary hypertension (PH), and chronic obstructive pulmonary disease (COPD), cause significant global morbidity and mortality.
- Existing disease models fail to capture the dynamic in vivo pathogenesis, leading to a gap between basic research and clinical outcomes.
- Limited clinical management options exist for these devastating conditions.
Purpose of the Study:
- To review how engineering principles are applied to characterize human lung tissues and model pathogenic alterations.
- To highlight the role of precision biomaterials and advanced biomanufacturing in developing organotypic disease models.
- To discuss strategies for accelerating the development and validation of personalized therapies for chronic pulmonary diseases.
Main Methods:
- Characterization of dynamic changes in the structure, mechanics, and composition of the extracellular matrix in chronic pulmonary diseases.
- Application of engineering principles to create in vitro models that recapitulate in vivo pathogenic alterations.
- Review of advances in biomaterial design and biomanufacturing for personalized medicine approaches.
Main Results:
- Advances in lung tissue characterization reveal dynamic extracellular matrix changes in chronic pulmonary diseases.
- Tissue-informed engineering approaches are paving the way for more organotypic models of human pathology.
- Precision biomaterials and biomanufacturing offer opportunities to overcome translational challenges.
Conclusions:
- Engineering strategies using precision biomaterials and advanced biomanufacturing hold revolutionary potential for pulmonary disease modeling.
- These approaches can bridge the gap between basic research and clinical outcomes by creating more accurate disease models.
- The integration of personalized medicine principles can accelerate the development of novel therapeutics for chronic pulmonary diseases.
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