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Updated: Feb 2, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
Published on: April 25, 2025
The effect of coenzyme Q and selenium on kidney in rats with partial unilateral ureteral obstruction
Mustafa Koray Kırdağ1, Devrim Tuğlu1, Ercan Yuvanç1
1Department of Urology, Kırıkkale University School of Medicine, Kırıkkale, Turkey.
Objective:
In this study, we aimed to investigate the antioxidant effects of selenium and coenzyme Q on renal damage in a partial unilateral ureteral obstruction (PUUO) in a rat model.
Material And Methods:
A total of 24 Sprague-Dawley rats were divided into four groups as Group 1 Control Group, Group 2, PUUO Group, Group 3 PUUO + coenzyme Q group, Group 4 PUUO + selenium group. Paraoxonase (PON), total antioxidant capacity (TAC), and total oxidant levels (TOS) were analyzed biochemically from tissue and blood samples. Tissue samples were examined histopathologically.
Results:
The TAC in the tissues was found to be statistically significantly increased in Groups 3 and 4, compared to Group 2. Tissue TOS was found to be significantly reduced in Groups 3 and 4, compared to Group 2. Serum PON levels were significantly increased in Group 3 and 4, compared to Group 1 and 2. Histopathological examination showed that interstitial inflammation and congestion were lesser in the coenzyme Q and selenium groups than in the PUUO group. A more significant decrease was found in the selenium group than in the coenzyme Q group.
Conclusion:
Our study results showed that coenzyme Q and selenium reduced the oxidation and the damage in tissue in PUUO in rats.
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