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Updated: Feb 2, 2026

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Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition

Seon-Hyeong Lee1, Won-Kyu Lee2,3, Nayeon Kim4,5

  • 1Tumor Microenvironment Research Branch, Division of Cancer Biology, National Cancer Center, Goyang, Gyeonggi-do 10408, Korea. shlee1987@gmail.com.

Cancers
|November 23, 2018
PubMed

Insights

Streptonigrin inhibits transglutaminase 2 (TGase 2) in renal cell carcinoma (RCC), stabilizing p53 and inducing cancer cell death. This suggests targeting TGase 2 is a promising therapeutic strategy for RCC.

Area of Science:

  • Oncology
  • Biochemistry
  • Molecular Biology

Background:

  • Transglutaminase 2 (TGase 2) is upregulated in renal cell carcinoma (RCC), leading to p53 instability.
  • TGase 2 binds to and facilitates the degradation of p53 in RCC.
  • Inhibiting TGase 2 promotes p53-mediated apoptosis in RCC.

Purpose of the Study:

  • To identify TGase 2 inhibitors for potential RCC therapy.
  • To investigate the therapeutic potential of streptonigrin in RCC.

Main Methods:

  • Screening a chemical library for TGase 2 inhibitors.
  • Surface plasmon resonance and mass spectrometry to confirm streptonigrin-TGase 2 binding.
  • In vitro and in vivo assays to evaluate streptonigrin's anti-cancer effects in RCC models.

Main Results:

  • Streptonigrin was identified as a TGase 2 inhibitor.
  • Streptonigrin binds to TGase 2 at amino acids 95-116, inhibiting its activity and stabilizing p53.
  • Streptonigrin demonstrated anti-cancer effects in RCC cell lines and a preclinical RCC model.

Conclusions:

  • Targeting TGase 2 with streptonigrin represents a novel therapeutic strategy for RCC.
  • Streptonigrin's ability to stabilize p53 and induce apoptosis offers a new avenue for RCC treatment.
Keywords:
apoptosisp53renal cell carcinomastreptonigrintransglutaminase 2

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