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An In Vitro Organ Culture Model of the Murine Intervertebral Disc
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Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc.

Sarah E Gullbrand1,2, Beth G Ashinsky1,2,3, Edward D Bonnevie1,2

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Tissue-engineered disc replacements (eDAPS) show functional integration and mechanical maturation in rat and goat models. This demonstrates the potential of tissue engineering for treating intervertebral disc degeneration.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Intervertebral disc degeneration is a significant cause of back pain.
  • Current treatments for advanced disc degeneration are limited.
  • Tissue engineering offers a promising approach for disc repair and regeneration.

Purpose of the Study:

  • To develop and evaluate tissue-engineered disc-like angle ply structures (eDAPS) for intervertebral disc replacement.
  • To assess the in vivo integration and mechanical function of eDAPS in large animal models.
  • To demonstrate the translational feasibility of eDAPS for treating advanced disc degeneration.

Main Methods:

  • Engineered eDAPS mimicking native disc hierarchical structure, sized for rat caudal and goat cervical spines.
  • Implantation of eDAPS in rat caudal and goat cervical disc replacement models.
  • Long-term in vivo assessment of eDAPS composition, structure, mechanical properties, and functional integration.

Main Results:

  • In rats, eDAPS achieved native compressive mechanical properties and functional integration after 20 weeks.
  • In goats, eDAPS maintained composition and structure up to 8 weeks.
  • Goat eDAPS demonstrated maturation of compressive mechanical properties to native levels.

Conclusions:

  • Tissue-engineered eDAPS show functional maturation and integration in vivo.
  • eDAPS demonstrate translational feasibility for treating advanced intervertebral disc degeneration.
  • This approach holds promise for clinical translation in treating disc degeneration.