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Cephalexin-induced acute generalized exanthematous pustulosis.
Matthew DaCunha1, Sarah Moore1, David Kaplan1
1University of Kansas Medical Center, Kansas City, Kansas, USA.
Dermatology Reports
|November 23, 2018
Summary
Cephalexin, a common antibiotic, can rarely cause Acute Generalized Exanthematous Pustulosis (AGEP). This case highlights AGEP as a potential adverse effect of cephalexin, aiding clinical diagnosis.
Area of Science:
- Pharmacology
- Dermatology
- Infectious Diseases
Background:
- Cephalexin is a widely prescribed cephalosporin antibiotic.
- Infectious diseases are a common indication for cephalexin therapy.
- Adverse drug reactions require continuous monitoring and reporting.
Purpose of the Study:
- To report a rare case of drug-induced Acute Generalized Exanthematous Pustulosis (AGEP).
- To associate cephalexin with the development of AGEP.
- To increase clinician awareness of AGEP as a potential cephalexin adverse effect.
Main Methods:
- Case report presentation.
- Clinical assessment of a patient with a skin reaction.
- Review of relevant medical literature.
Main Results:
- A patient developed Acute Generalized Exanthematous Pustulosis (AGEP).
- The adverse event was attributed to cephalexin administration.
- This represents a rare documented association between cephalexin and AGEP.
Conclusions:
- Cephalexin can induce Acute Generalized Exanthematous Pustulosis (AGEP).
- Clinicians should consider AGEP in the differential diagnosis for patients on cephalexin presenting with specific dermatological symptoms.
- Further reports are needed to fully understand the incidence and risk factors of cephalexin-induced AGEP.
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