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Conidiobolus coronatus infection treated with ketoconazole
L Towersey1, B Wanke, R R Estrella
1Division of Dermatology, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Niterói, Brazil.
Archives of Dermatology
|September 1, 1988
Summary
A rare subcutaneous zygomycosis infection caused by Conidiobolus coronatus, lasting six years, was successfully treated with ketoconazole after potassium iodide failed. The patient remained disease-free for three years post-therapy, highlighting effective treatment options for this fungal infection.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Dermatology
Background:
- Subcutaneous zygomycosis is a rare fungal infection.
- Conidiobolus coronatus and Basidiobolus ranarum are the primary agents of subcutaneous zygomycosis.
- This condition can be chronic and challenging to treat.
Observation:
- A six-year-long case of subcutaneous zygomycosis caused by Conidiobolus coronatus is presented.
- The patient initially received potassium iodide treatment without success.
- Ketoconazole therapy was initiated for the persistent infection.
Findings:
- The patient showed a positive response to ketoconazole therapy.
- The infection resolved, and the patient remained well for three years after treatment completion.
- A review of Brazilian cases of subcutaneous zygomycosis caused by C. coronatus and B. ranarum is included.
Implications:
- Ketoconazole is an effective treatment for recalcitrant subcutaneous zygomycosis caused by Conidiobolus coronatus.
- This case highlights the importance of considering alternative antifungal therapies when initial treatments fail.
- Understanding the epidemiology of these fungal infections in specific regions, like Brazil, is crucial for public health.