Related Experiment Video
Updated: Feb 2, 2026

Endoscopic Approach for Colloid Cyst Resection
Published on: May 23, 2025
Efficacy Of Phenylephrine Infusion Verses Colloid Preloading In Resolving Hypotension Due To Spinal Anaesthesia
Azmat Ali Shah1, Ahsan Rasool1, Muhammad Adeel Alam2
1Department of Anaesthesiology, Ayub Teaching Hospital, Abbottabad, Pakistan.
Background:
Spinal anaesthesia causes hypotension that is countered through various methods. Phenylephrine is a vasoconstrictor and haemocoel increases the intravascular vascular volume; both have an effect in preventing this hypotension; but their comparison has not been done in local setting.
Methods:
Randomized control trial was conducted in month of June, 2017 at Ayub Teaching Hospital, Abbottabad. Block randomization with sealed envelopes was employed. Sample size was set at 90. Two equal groups were formed; Group A received 500 ml of haemocoel before spinal anaesthesia administration and Group B received 300μg of phenylephrine in 100ml infusion over 3 minutes..
Results:
An average drop of 8.2 mmHg, 9.7 mmHg and 3.1 mmHg in MAP was observed in Group A participants at 5 minutes, 10 minutes and 15 minutes respectively after spinal anaesthesia. In Group B, an average drop of 1.2mmHg was observed in first 5 minutes. MAP did not change significantly from this value throughout the monitoring period. There was a drop of 1.2 mmHg at 5 minutes in group B. After this, no further drop in blood pressure was observed.
Conclusions:
Phenylephrine infusion is better than haemocoel preload in preventing hypotension due to spinal anaesthesia.
Related Concept Videos
Colloids
Colloids and Suspensions
Colloidal precipitates
Self-Efficacy
One-Compartment Model: IV Infusion
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
Two-Compartment Open Model: IV Infusion
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...

