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Related Concept Videos

Introduction to Connective Tissues01:11

Introduction to Connective Tissues

14.9K
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
14.9K
Classification of Connective Tissues01:30

Classification of Connective Tissues

15.9K
The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....
15.9K
Embryonic Connective Tissues01:20

Embryonic Connective Tissues

6.5K
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
6.5K
Dense Connective Tissue01:13

Dense Connective Tissue

12.0K
Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
12.0K
Functions of Connective Tissues01:17

Functions of Connective Tissues

16.7K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
16.7K
Loose Connective Tissue01:26

Loose Connective Tissue

9.6K
Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
9.6K

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Updated: Feb 2, 2026

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
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Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

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Connective Tissue Disease: Current Concepts.

Anthony P Fernandez1

  • 1Departments of Dermatology and Pathology, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Avenue A61, Cleveland, OH 44195, USA.

Dermatologic Clinics
|November 24, 2018
PubMed
Summary
This summary is machine-generated.

Dermatologists play a key role in diagnosing and treating connective tissue diseases affecting the skin. This review covers updates on dermatomyositis, cutaneous lupus erythematosus, morphea, and cutaneous vasculitis to improve patient care.

Keywords:
Connective tissue diseaseCutaneous lupus erythematosusCutaneous vasculitisDermatomyositisMorphea

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Area of Science:

  • Dermatology
  • Rheumatology
  • Immunology

Background:

  • Connective tissue diseases frequently manifest with significant dermatologic symptoms.
  • Dermatologists are crucial for the accurate diagnosis and management of these conditions.
  • Understanding disease mechanisms and clinical presentations is vital for patient care.

Purpose of the Study:

  • To provide an updated overview of 4 major connective tissue diseases with prominent skin involvement.
  • To highlight recent advancements in understanding their pathogenesis, clinical features, and treatment.
  • To emphasize the role of dermatological expertise in managing these complex diseases.

Main Methods:

  • Literature review of recent research on selected connective tissue diseases.
  • Synthesis of information on pathogenesis, clinical manifestations, and therapeutic strategies.
  • Focus on conditions including dermatomyositis, cutaneous lupus erythematosus, morphea, and cutaneous vasculitis.

Main Results:

  • Recent research has yielded new insights into the pathogenesis of these diseases.
  • Updated clinical features aid in earlier and more accurate diagnosis.
  • Novel treatment approaches are emerging, promising improved patient outcomes.
  • Dermatologic manifestations are key diagnostic and prognostic indicators.

Conclusions:

  • Advances in understanding connective tissue diseases are enhancing dermatologic patient care.
  • Continued research by dermatologists is essential for further progress.
  • Improved diagnostic and therapeutic strategies will benefit patients with skin involvement.