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Pirfenidone improves survival in IPF: results from a real-life study

George A Margaritopoulos1,2, Athina Trachalaki1, Athol U Wells2

  • 1Respiratory Medicine Department, University Hospital of Heraklion, Crete, Greece.

BMC Pulmonary Medicine
|November 25, 2018
PubMed
Abstract

Insights

Pirfenidone treatment improved survival in idiopathic pulmonary fibrosis (IPF) patients in a real-world setting. Proactive management of side effects reduced treatment discontinuation, enhancing pirfenidone

Area of Science:

  • Pulmonology
  • Pharmacology
  • Real-world evidence studies

Background:

  • Pirfenidone is an approved antifibrotic medication for idiopathic pulmonary fibrosis (IPF).
  • Real-world data on pirfenidone's impact on mortality and adverse events is crucial outside clinical trial settings.

Purpose of the Study:

  • To evaluate the real-world effect of pirfenidone on mortality in IPF patients.
  • To assess the adverse events profile of pirfenidone in a clinical practice setting.
  • To compare survival rates between IPF patients treated with pirfenidone and a historical cohort.

Main Methods:

  • Retrospective observational intention-to-treat study.
  • Involved 82 consecutive IPF patients (UHH cohort).
  • Compared survival data with an IPF cohort from a tertiary referral center (RBH cohort).

Main Results:

  • A 3-year survival rate of 73% was observed in the UHH cohort, including patients who discontinued treatment.
  • Pirfenidone treatment was associated with significantly better survival compared to the RBH cohort, even after adjusting for age, gender, and FVC (HR:0.28, 95% CI: 0.16-0.48).
  • A similar safety profile to previous studies was noted, with a lower rate of discontinuation due to photosensitivity.

Conclusions:

  • Pirfenidone demonstrates a survival benefit in a real-world IPF patient cohort.
  • Effective patient counseling and proactive management of adverse effects can minimize pirfenidone discontinuation.
Keywords:
IPFPirfenidoneReal-lifeSurvival

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