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Iron deficiency and anemia in patients with inherited bleeding disorders

Heather VanderMeulen1, Michelle Sholzberg2

  • 1Department of Medicine, University of Toronto, Toronto, Canada.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|November 25, 2018
PubMed

Insights

Patients with inherited bleeding disorders often develop iron deficiency anemia (IDA). This review proposes aggressive iron supplementation and higher ferritin targets for these high-risk patients to improve their health and quality of life.

Area of Science:

  • Hematology
  • Internal Medicine
  • Genetics

Background:

  • Inherited bleeding disorders increase susceptibility to blood loss.
  • Iron deficiency anemia (IDA) significantly impacts general population health.
  • The prevalence and effects of IDA in bleeding disorder patients are understudied.

Purpose of the Study:

  • To review the diagnosis and management of iron deficiency (ID) in patients with inherited bleeding disorders.
  • To highlight the risks and clinical impact of ID and IDA in this population.
  • To propose optimized management strategies for ID in patients with bleeding disorders.

Main Methods:

  • Literature review of ID and IDA in inherited bleeding disorders.
  • Analysis of diagnostic approaches for iron deficiency.
  • Evaluation of current management strategies and proposed modifications.

Main Results:

  • Patients with inherited bleeding disorders are at high risk for ID and IDA due to blood loss.
  • ID and IDA can lead to reduced energy, impaired cognition, and decreased quality of life.
  • Current management may be insufficient for patients with ongoing bleeding risks.

Conclusions:

  • Aggressive iron supplementation is recommended for patients with ID and inherited bleeding disorders.
  • Higher target ferritin levels should be considered in these patients.
  • Optimized management can mitigate the adverse effects of ID and IDA, improving patient outcomes.

Keywords:
AnemiaInherited bleeding disorderIron deficiencyvon Willlebrand disease

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