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Updated: Feb 2, 2026

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
Synthesis and biological activities evaluation of sanjuanolide and its analogues
Jiadai Zhai1, Lin Fu2, Yuanyuan Li2
1School of Life Science, Shandong University of Technology, Zibo 255049, PR China; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
Abstract:
Sanjuanolide, psorachalcone A and its seven new analogues were synthesized via a combinatorial strategy by aldol reaction. In order to investigate the effect between electron density in π-conjugated systems and biological activities, several electron-withdrawing and electron-donating groups were introduced at C-4 and the phenolic hydroxyl groups of sanjuanolide. The two natural products and its seven new analogues were investigated for their inhibitory effects against five cancer cell lines. Moreover, the hydroxyisoprenyl group may be important to maintain the biological activities of sanjuanolide.
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